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KMID : 0359720140320010022
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Journal of the Korean Neurological Association
2014 Volume.32 No. 1 p.22 ~ p.25
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Anti-LGI1 Antibody Autoimmune Encephalitis Which Manifests Faciobrachial Dystonic Seizure
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Kim Hyun-Jin
Kim Bo-Mi
Hwang Ji-Hye
Lee Yoo-Jin
Lee Soon-Tae
Kang Joong-Koo
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Abstract
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Anti-LGI1 (leucine-rich glioma inactivated-1) antibody encephalitis is one of autoimmune encephalitis. We report a 66-year-old man who presented with frequent, brief dystonic seizures which involve predominantly ipsilateral face and arm without cognitive impairment. Brain MRI showed normal finding. Serum and CSF tests revealed anti-LGI1 antibody. His symptom was not relieved by antiepileptic drugs, but completely controlled after immunotherapy. This case indicates that recognition of the brief, dystonic seizures should do tests for anti-LGI1 antibodies.
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KEYWORD
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Autoimmune encephalitis, LGI1, Voltage gated potassium channel
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